It is not exactly clear whether the exciting potential of combinatorial chemistry research and development in the 1990s led to new products. After about a decade or so of intense activity and excitement, the field seemed to fade away. Today, synthetic chemists, artificial intelligence, machine learning, big data, supercomputers, computer simulations, and robotics appeared on our radar. At breakneck speed they started to take off where combinatorial chemistry had left off and the self-driving chemistry laboratory and artificial chemist made their debut. It will be very interesting to see if the “next industrial revolution” will be spawned by this new wave of computational materials research. See full article at Advanced Science News.